hypersensitivity reaction

Hypersensitivity reaction
Sometimes the immune response is overreactive against foreign antigen Or reacts against it's own tissue. 
Hypersensitivity reaction can be classified according to the source of antigen Or basic Immunologic mechanisms causing the injury. Four type of hypersensitivity reactions -
Type 1: lgE- Mediated Reaction
Type 2: Cytotoxic
Type 3: Immune - Complex
Type 4: Delayed hypersensitivity
Type 1: lge mediated reaction:- Anaphylactic reaction are type 1 reaction that occur only in susceptible people who are highly sensitized to specific allergens. IgE antibodies, produced in response to the allergen, have a characteristics property of attaching to mast cell and basophils. 
Type 2: Cytotoxic and Cytolytic reaction:- are type 2 hypersensitivity reaction involving the direct binding of IgG or IgM antibodies to an antigen on the cell surface. Antigen - antibody complexes activate the complement system, which mediates the reaction. Cellular tissue is destroyed in one of two ways (1) activation of the complement system resulting in cytolysis or (2) enchanced phagocytosis. 
Type 3: Immune- Complex Reaction:- tissue damage in immune - complex reaction, which are type 3 reaction, occur secondary to antigen- antibody complexes. Soluble antigen combine with immunoglobulin of the IgG and IgM classes to from complexes that are too small to be effectively removed by the mononuclear Phagocyte system. 
Type 4: Delayed hypersensitivity reaction:- A delayed hypersensitivity reaction- a type 4 reaction is also called a cell mediated immune response. Although cell- mediated response are usually protective mechanisms, tissue damage occur in delayed hypersensitivity reaction. 

Complication of plaster casts

 COMPLICATION OF PLASTER CASTS

Complication

Sign and symptoms

1.      Impaired blood flow

Absences of pulse in the extremity below the plaster cast.

Pallor, blanching or cyanosis of the skin.

Pain

Coldness of the skin.

Swelling

Numbness

Motor paralysis

2.      Nerves damage

Persistent and increasing pain.

Numbness

Motor paralysis

3.      Tissue necrosis and infection

Unpleasant odour

Feeling of hot sensation

Drainage through the cast.

Sudden elevation of unexplained body temperature.

4.      Volkman’s ischemic contracture

All the sign and symptoms of impaired blood flow.

Absence of radial/pedal pulse.

Infraction and necrosis of the muscles.

Absences of the finger/ toe movements.

Absences of the pain which was intense in the beginning.

5.      Cast syndrome

Prolonged nausea and vomiting.

Abdominal distension.

Vague abdominal pain.

6.      Complication due to immobility

 

Hypostatic pneumonia.

Foot drop

Renal calculi

Stiffness of joints

 

7.      Surgical complication

Insomnia

Phlebo – thrombosis and pulmonary embolism.

Wound infection.

 


Types of pelvic

 pelvic is divided in to 4 types according to the shape of the brim.

1. Gynecoid - 

it is normal female pelvic. this type of pelvic seen in 50% females. 

INLET

Shapes - Round 

anterior posterior segments - almost equal and spacious.

CAVITY 

Sacrosciatic notch - wide and shallow

Sidewall - straight or slightly divergent .

OUTLET

ischial spines - not prominent

pubic arch - curved

subpubic angle - wide 

Bituberous diameter -  Normal 

2. Anthropoid - 

INTEL 

shape - anterior posterior oval 

anterior and posterior segment - both increased with slight anterior narrowing.

CAVITY

sacrosciatic notch - more wide and shallow 

side wall - straight or divergent 

OUTLET

ischial spines - not prominent

pubic arch - long and curved 

subpubic angle - slightly narrow 

Bituberous diameter - normal or short.

3. Android 

INLET

shape - triangular, Heart shape 

anterior and posterior segment - posterior segment short and anterior segment narrow

CAVITY

sacrosciatic notch - narrow and deep

sidewall - convergent

OUTLET

Ischial spine - prominent

pubic arch - long and straight

subpubic angle - narrow 

Bituberous diameter - short

4. Platypelloid 

INLET

shape - transversely oval

anterior and posterior segment - both reduced flat

CAVITY

sacrosciatic notch - slightly narrow and small

sidewall - divergent

OUTLET

ischial spines - not prominent 

pubic arch - short and curved 

subpubic angle - very wide (more than 90)

Bituberous diameter - wide


drugs of choice

Drug of choices for gonorrhea – ceftriaxone

Drug of choices for hyperthyroidism – prothiouracil

Drugs of choices in hypothyroidisms – levothyroxine                                                                                    

Drug of choices for hyperthyroidism in children – thyroxine

Drugs of choices for hyperprolactinemia – bromocriptine

Drugs of choices for ectopic pregnancy – methotrexate

Drugs of choices for induction of labor – oxytocin

Drugs of choices for asthma – beta agonist

Drugs of choices for postpartum breast engorgement – oxytocin

Drug of choices for seizure in eclampsia – magnesium sulphate

Drug of choice for malaria in pregnancy – chloroquine

Drugs of choices for anticoagulation in pregnancy – heparin

Type 2 DM – metformin

Ectopic pregnancy – methotrexate

ECT – methohexitone

Epilepsy – thiopentone

Groups B streptococcal infection – ampicillin

Rheumatic fever – benzathine penicillin

Anaphylactic shock – adrenaline

Septic shock – broad spectrum antibiotics

Open angle glaucoma – latanoprost


True labor pain and false labor pains

True labor pain :-
The pain arises in back, radiates to the front of abdomen and thighs
Intermittent in nature with increase in intensity, frequency and duration. 
Associated with hardening of uterus due to retraction of muscle fibers. 
Expulsion of show which is the mucus plug mixed with blood from the ruptured capillaries of the cervix. 
Dilation of internal os. 
Formation of bag of water due to stretching of the lower uterine segment and detachment of membrane from decidua. 
Pain occur due to uterine contraction. 
False labor pain :-
Pain occur in the lower abdomen and groin only and remains stationary in the lower abdomen. 
Pain continuous without any rhythmicity. 
There is no harding of uterus. 
No effect on dilatation of cervix and no show. 
No formation of bag of waters. 
Pain diminishes after enema. 

obstetrics terminology

 

                                               Terminology

Nullipara – A women who has never completed her pregnancy to the state of viability.

Nulligravida – A women who is not now and never has been pregnant.

Primipara – women who has delivered on viable child.

Primigravida – A women who is pregnant for the first time.

Multigravida – women who has previously been pregnant. She may have aborted or have delivered a viable birth.

Multipara – A women who has completed two or more pregnancy to the state of viability. 

Parturient – A women who is in labor consider parturient.

Puerpera – A women who has just given birth to the baby.


sign of complication of intravenous therapy

,
                  SIGN OF COMPLICATION OF INTRAVENOUS                                                    THERAPY

  1. Air embolism :-  it is define as a bolus of air enter the vein through an inadequately primed IV line, from a loose connection, during tubing change, or during removal of the IV. 
Prevention and intervention -
• prime tubing with fluid before use, and monitor for any air bubbles in the tubing. 
• secure all connections. 
• replace the IV fluid before the bag or bottle is empty. 
• monitor for sign of air embolism, if suspected clamp the tubing, turn the client on the left side with head of the bed lowered ( Trendelenburg position ) to trap the air on the right atrium and notify the senior staff or doctor. 
2. Catheter embolism :- it is define as an obstruction that results from breakage of the catheter tip during IV line insertion or removal. 
Prevention and intervention :-
• remove the catheter carefully.
• inspect the catheter when removed. 
• if the catheter tip has broken off, place a tourniquet as proximally as possible to the IV site on the affected limb, notify the senior or doctor immediately,  prepare to obtain a radiograph, and prepare the client for surgery to remove the catheter piece if necessary. 
3. Circulatory overload :-  it is also known as FLUID OVERLOAD,  result from the administration of fluid too rapidly, especially in a client at risk for fluid overload 
Prevention and intervention :- 
•identity client at risk for circulatory overdose. 
• calculate and monitor the drip ( flow) rate frequently. 
• use an electronic IV  infusion device and frequently check the drip rate or setting at least every hours. 
• add a time label to the IV bag or bottle next to the volume markings. 
• . Monitor for sign of circulatory overdose. If circulatory overdose occur, decrease the flow rate to a minimum, at a keep vein open rate, elevate the head of the bed, keep the client warm, assess lung sounds, assess for edema, and notify the senior or doctor. 
 Client with respiratory, cardiac, renal or liver disease, older client and very young person's are at the for circulatory overdose and cannot tolerate excessive fluid volume. 
4. Electrolyte overdose :- it is define as an electrolyte imbalance is caused by too rapid or excessive infusion or by use of an inappropriate IV solution. 
Prevention and intervention :-
• assess laboratory value reports. 
verify the correct solution. 
• calculated and monitor the flow rate.
place a red medication sticker on the bag or bottle if a medication has been added to the IV solution. 
• monitor for sign of an electrolyte imbalance, and notify the senior. 
Lactated Ringer's solution contains potassium and should not be administered to client with acute kidney injury or chronic kidney disease. 
5. Hematoma :-  the collection of blood in the tissue after an unsuccessful vein puncture or after the vein puncture site is discontinued and blood continues to ooze the tissue.
Prevention and intervention :-
• when starting an IV, avoid piercing the posterior wall of the vein.
• do not apply a tourniquet to the extremity immediately after an unsuccessful vein puncture. 
• when discontinuing an IV, apply pressure to the site for 2 to 3 minutes and elevate the extremity. 
if a hematoma develops, elevate the extremity and apply pressure and ice. 
6. Infection :-  infection occurs from the entry of microorganisms into the body through the vein puncture site.
prevention and intervention :- 
  •  maintain asepsis when caring IV site.
  • monitor for sign of local or systemic infection.
  • monitor WBC count
  • change IV tubing every 96 hours in according agency policy 
  • label the IV site bag, bottle and tubing with date to ensure that these are changed.
  • ensure that IV solution is not hanging for more than 24 hours.
a client with diabetes mellitus usually does not receive dextrose (glucose) solution because the solutions can increase the blood glucose level.
7. Infiltration :- infiltration is seepage of the IV fluid out of the vein and into the surrounding interstitial spaces.
prevention and intervention :- 
  •  avoid vein puncture over an flexion.
  • anchors the cannula and a loop of tubing securely with tape.  
  • use an arm board or splint as needed if the client is restless or active.
  • evaluate the IV site for infiltration by occluding the vein proximal to the IV site.
  • if the infiltrations has occurs remove the IV device immediately.

8. Phlebitis and thrombophlebitis :- phlebitis is an inflammation of the vein that can occurs from mechanical or chemical trauma or from local infection.
phlebitis can cause the development of a clot (thrombophlebitis).
prevention and intervention:-
  •  use the IV cannula smaller than the vein and avoid using very small vein when administering irritating  solutions.
  • avoid using  the lower extremity( leg and feet) as an access area for the IV.
  • change vein puncture site every 72 to 92 hours in according to agency policy.
  • if phlebitis occurs remove IV devices.

9. tissue damage :- tissues are most common damaged include skin, veins and subcutaneous tissues.
extravasation is a from of tissues damage caused by the seepage of vesicants or irritating solutions into the tissues.
prevention and intervention :-    
  •  use a careful and rental approach when applying a tourniquet.
  • avoid tapping the skin over the vein when starting an IV.
  • monitor ecchymosis when penetrating the skin with the cannula,.
  • monitor skin color change, sloughing of the skin or discomfort at the IV sites.
always documentation the occurrence of a complication assessment finding action taken and client response.



Complication

sign

Air embolism

Tachycardia

Chest pain or dyspnea

Hypotension

Cyanosis’

Decreased level of consciousness

Catheter embolism

Decreased in blood pressures

Pain along the vein

Weak, rapid pulse

Cyanosis of the nail beds

Loss of consciousness

 

Circulatory overload

Increase blood pressure

Distended jugular vein

Rapid breathing

Dyspnea

Moist cough and crackles

Electrolyte overload

Sign depend on the specific electrolyte overload

hematoma

Ecchymosis, immediate swelling and leakage of blood at the site,

Hard and painful lumps  at the site

infection

Local – redness, swelling and drainage at the site

Systemic – chills ,fever, malaise, headache, nausea , vomiting, backache, tachycardia

Infiltration

Edema, pain, numbness and coolness at the sites; may or may not have a blood return

Phlebitis

Heat, redness, tenderness at the sites

Not swollen or hard

Intravenous infusion sluggish

thrombophlebitis

Hard and cordlike vein , heat, redness, tenderness at the sites

Tissues damage

Skin color changes, sloughing of the skin,

Discomfort at the sites

 












do not rub the an infiltration area , which can cause hematoma.


hypersensitivity reaction

Hypersensitivity reaction Sometimes the immune response is overreactive against foreign antigen Or reacts against it's own tissue.  Hype...

vital sign